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Effect of oxytocin on gastric ischemia-reperfusion injury in rats

ZHANG Wenwen, ZHANG Jianfu, ZHANG Yongmei, XU Ming

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 433-437 doi: 10.1007/s11684-007-0085-4

Abstract: , and those of the OT group were (102.45±48.00) μL, 2.65±0.40 ( = 6) res pectively; differences had statisticalsignificance (<0.01).

Keywords： control     significant difference     surgical     statistical significance     Sprague-Dawley    

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Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

Yi Cao

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 261-274 doi: 10.1007/s11684-015-0406-y

Abstract: In this review, the roles of DNA methylation in carcinogenesis and their significance in clinical medicine

Keywords： environmental pollution     DNA methylation     cancer     biomarker     diagnosis     therapy     prevention    

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Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 87-94 doi: 10.1007/s11684-008-0016-z

Abstract: The biological behavior of gastrointestinal stromal tumors (GISTs) are highly variable. To investigate the biological behavior of GIST, we collected 83 cases of gastric and 62 cases of small intestinal GIST from the Department of Pathology of the Chinese PLA General Hospital. The parameters include age, primary tumor location, tumor diameter, mitotic index, tumor necrosis, risk assessment, clinical stage and the exon 11 mutation. All these were analyzed in 105 cases along with the follow-up data and tested by log rank and COX hazard proportional model. We find that the average age of gastric GIST was 55.4 years. Of the 62 cases that were followed up, 17 cases had metastasis or recurrence and the 5-year survival rate was (66.51 ± 17.06)%. For the small intestinal GIST, the average age was 50.6 years and 43 cases were followed up. Of these, 22 cases had metastasis or recurrence and the 5-year survival rate was (61.76 ± 18.30)%. Small intestinal GIST was more frequently associated with metastasis and tumor relapse than gastric GIST ( = 6.131, = 0.013). For gastric GIST, patients younger than 50 years ( = 0.046), the advanced clinical stage ( = 0.0001), the large tumor diameter ( = 0.0001), a high mitotic index ( = 0.0001), necrosis ( = 0.0001) and a high risk grade ( = 0.004) were all correlated with a lower survival rate. The COX hazard proportional model revealed that advanced clinical stage ( = 0.001), large tumor size ( = 0.001), a high mitotic index ( = 0.002) and the high risk grade ( = 0.018) indicated a poorer prognosis in gastric GIST. For small intestinal GIST, necrosis ( = 0.036) and advanced clinical stage ( = 0.010) were associated with lower survival rates and the clinical stage was shown to be an independent prognostic indicator. A total of 25 cases harbored mutations in exon 11. The frequency of mutation was 32% and 22.5% for gastric and small intestinal GIST, respectively. In gastric GIST, the mutated was predominant in patients older than 50 years of age. But in the small intestinal GIST, the mutated was predominant in the age group of 40–49 years. In conclusion, for gastric GIST, clinical stage, tumor size, mitotic index, and risk grade are the prognostic indicators. For small intestinal GIST, necrosis and clinical stage are the prognostic indicators. Small intestinal GIST are more aggressive than gastric GIST. The occurrence of mutation may correlate with the age of patients.
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Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice

ZHU Lidong, CHEN Xiaoping

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 364-368 doi: 10.1007/s11684-007-0070-y

Abstract: The aim of this article was to study the influence of immunity function of advanced malignant obstructive jaundice (MOJ) treated by percutaneous transhepatic biliary external and internal drainage. Ninety-six cases of MOJ were divided into two groups according to the different ways of biliary drainage. Fifty-two external drainage tubes were placed in 41 cases of percutaneous transhepatic biliary external drainage group and 66 metal stents were placed in 55 cases of percutaneous transhepatic biliary internal drainage group. Liver function, serum TNF- and cellular function were examined one day before operation and one week after operation and liver function was re-examined two weeks after operation, in order to observe the change and analyze the asso ciation among them and compare with the control group. All patients conditions were improved after operation. In the percutaneous transhepatic biliary external and internal drainage groups, the total level of bilirubin decreased from (343.54±105.56) μ mol/L and (321.19±110.50) μ mol/L to (290.56±103.46) μ mol/L and (283.72±104.95) μ mol/L after operation respectively, which were significantly lower than pre-operation (<0.05), but there was no significant difference between the two groups (>0.05). Serum alanine aminotransferase (ALT) of all patients one week after operation was significantly lower than that before operation. TNF- in percutaneous transhepatic biliary external and internal groups decreased from (108.58±19.95) pg/mL, (109.98±16.24) pg/mL of pre-operation to (104.32±19.59) pg/mL, (83.92±13.43) pg/mL of post-operation respectively, there was notable improvement (<0.01) in internal drainage group after operation. Patients serum CD4, CD3 and CD4/CD8 were notably increased, but CD8 was notably decreased (<0.05). There was no difference in external drainage group (>0.05). There was a significant difference between the two groups. Serum TNF- and ALT had positive correlation. Percutaneous transhepatic biliary internal or external drainage was an effective and important method to treat MOJ. Patients immune function was weak when they suffered MOJ, but body s cellular immune function can be notably improved after internal biliary drainage.
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Factor analysis for the statistical modeling of earthquake-induced landslides

Jeng-Wen LIN, Meng-Hsun HSIEH, Yu-Jen LI

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 1,   Pages 123-126 doi: 10.1007/s11709-019-0582-y

Abstract: Earthquake-induced landslides are difficult to assess and predict owing to the inherent unpredictability of earthquakes. In most existing studies, the landslide potential is statistically assessed by collecting and analyzing the data of historical landslide events and earthquake observation records. Unlike rainfall-induced landslides, earthquake-induced landslides cannot be predicted in advance using real-time monitoring systems, and the development of the models for these landslides should instead depend on early earthquake warnings and estimations. Hence, in this study, factor analysis was performed and the frequency distribution method was employed to investigate the potential risk of the landslides caused by earthquakes. Factors such as the slope gradient, lithology (geology), aspect, and elevation were selected and classified as influential factors to facilitate the construction of a landslide database for the area of study.

Keywords： earthquake     factor analysis     slope landslides     statistical modeling    

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Analysis on the distinguishing features of traditional Chinese therapeutics and related statistical issues

Jingqing Hu, Jie Qiao, Deying Kang, Baoyan Liu

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 203-207 doi: 10.1007/s11684-011-0138-6

Abstract: Some statistical problems are raised based on these features.First, complex statistical methods that can analyze subjective indexes and latent variables, multidimensional

Keywords： traditional Chinese therapeutics     feature     statistic    

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Recent development on statistical methods for personalized medicine discovery

Yingqi Zhao, Donglin Zeng

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 102-110 doi: 10.1007/s11684-013-0245-7

Abstract: Recently, a number of new statistical methods have been developed to tackle the important problem of

Keywords： dynamic treatment regimes     personalized medicine     reinforcement learning     Q-learning    

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Statistical considerations for genomic selection

Huimin KANG, Lei ZHOU, Jianfeng LIU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 268-278 doi: 10.15302/J-FASE-2017164

Abstract: This review covers the most commonly used statistical methods and some extensions of them, i.e., ridge

Keywords： genomic estimated breeding value     genomic selection     linkage disequilibrium     statistical methods    

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Statistical process control with intelligence using fuzzy ART neural networks

Min WANG, Tao ZAN, Renyuan FEI,

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 2,   Pages 149-156 doi: 10.1007/s11465-010-0008-y

Abstract: been gradually employed to increase the automation and intelligence degree in quality control using statistical

Keywords： statistical process control (SPC)     fuzzy adaptive resonance theory (ART)     histogram     control chart     time    

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Assessment of temporal and spatial variations in water quality using multivariate statistical methods

Xue LI,Pengjing LI,Dong WANG,Yuqiu WANG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 6,   Pages 895-904 doi: 10.1007/s11783-014-0736-z

Abstract: spatial variations of water quality data sets for the Xin'anjiang River through the use of multivariate statistical

Keywords： Xin'anjiang River     multivariable statistical analysis     temporal variation     spatial variation     water quality    

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Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle

Zhonggao Wang,Zhiwei Hu,Jimin Wu,Feng Ji,Hongtao Wang,Yungang Lai,Xiang Gao,Yachan Ning,Chengchao Zhang,Zhitong Li,Weitao Liang,Jianjun Liu

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 117-122 doi: 10.1007/s11684-014-0343-1

Abstract:

At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux (GER) insults on our own airway. Symptoms of GER are commonly seen as heartburn and regurgitation, which can be mostly tolerated. However, when the up going gastric content reversely passes the esophagus and then the distal pharynx, where it appears a beak like stricture, serving as a nozzle, so as to produce numerous micro-particles and reach the oro-nasal cavity and also the airway causing allergic rhinitis and asthmatic attacks, even pulmonary parenchyma lesions. It will reduce life quality or even jeopardize life. The point that the endogenous insult appears in the respiratory system, but originates from the digestive tract is not well known and often undiagnosed and not correctly treated. The GER induced airway challenge is a treatable and preventive entity, as soon as a diagnosis is made, a good relief could be expected by means of life style adjustment, medicine, or fixation of the patulous cardia through radiofrequency or fundoplication. The author Dr. Zhonggao Wang had suffered it for long and symptoms disappeared for 8 years after anti-reflux surgery. Here is a presentation of Dr. Zhonggao Wang and his team’s work and would call attention to the public so as to recognize this relatively unknown entity — a treatable condition occurring from human itself, but not from outside surroundings as smoking or haze does.

Keywords： gastroesophageal reflux     airway     pharyngeal nozzle     micro-aspiration     asthma    

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Scientific significance of ancient maps of Yellow River and Grand Canal for water conservancy in China

Xiaocong LI,

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 4,   Pages 445-454 doi: 10.1007/s11709-009-0063-9

Abstract: Based on the study of ancient maps preserved in China and abroad, the systematic nature and practical meaning of the maps of the Yellow River and Grand Canal is demonstrated. It is pointed out that the ancient maps not only record the spatial information of the established water conservancy engineering for river harnessing but also the management systems of the rivers in history. Besides, the maps provide abundant information on nature, humanity, and geography and possess high value in academic research and art appreciation.

Keywords： information     management     established     appreciation     practical    

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Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 264-270 doi: 10.1007/s11684-010-0094-6

Abstract: Cervical lesions have been regarded as the common and frequently occurring diseases in China. Recently, the morbidity and youth tendency of cervical cancer have gradually increased. Cervical cancer, related with human papilloma virus (HPV) infection, has been one of the severest diseases threatening health and life of women, and is an infectious disease. The universality of HPV infection in the reproductive tract should not be ignored. The well-known risk factors of HPV infection in cervical lesions consist of high-risk sexual behaviors, immunosuppression, age, contraceptive methods, the concurrent infection of other sexually transmitted diseases, etc. The variation of cervical lesions induced by HPV infection is involved in the continuous pathological process, including the subclinical, latent, and persistent infection of high risk (HR)-HPV, chronic cervicitis with abnormal results of cytological examination, cervical intraepithelial neoplasia (CIN), and cervical cancer. The outcome of patients with HPV infection is influenced by many factors, such as HPV subtype dominance, persistent HPV infection, HPV loading dose, and multiple HPV infection. Controlling HR-HPV persistent infection should be an important strategy for reducing cervical lesions.

Keywords： cervical lesion     high risk-human papilloma virus     persistent infection     loading dose     cervical intraepithelial neoplasia     cervical cancer    

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Increasing significance of advanced physical/chemical processes in the development and application of

RULKENS Wim

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 4,   Pages 385-396 doi: 10.1007/s11783-008-0073-1

Abstract: microbiological treatment methods are, only to a limited part, able to satisfy these needs, the role and significance

Keywords： control     beneficial     valuable     scarcity     Development    

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Application of statistical design for the production of inulinase by

M. DILIPKUMAR, M. RAJASIMMAN, N. RAJAMOHAN

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 4,   Pages 463-470 doi: 10.1007/s11705-011-1112-1

Abstract: A Plackett-Burman design was employed for screening 18 nutrient components for the production of inulinase using sp. and pressmud as the substrate via solid-state fermentation (SSF). From the experiments, three nutrients viz. yeast extract, FeSO ·7H O, and NH NO were found to be the most significant components. Hence these three components were selected and optimized using Response Surface Methodology (RSM). The optimum conditions are: yeast extract 0.00274 g/gds, FeSO ·7H O 0.00011 g/gds and NH NO 0.00772 g/gds. The effect of the substrate concentration and initial moisture content were also studied. A substrate concentration of 12 g and an initial moisture content of 65% are optimum for the maximum production of inulinase (89 U/gds).

Keywords： inulinase     pressmud     Response Surface Methodology (RSM)     streptomyces sp    

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Title Author Date Type Operation

Effect of oxytocin on gastric ischemia-reperfusion injury in rats

ZHANG Wenwen, ZHANG Jianfu, ZHANG Yongmei, XU Ming

Journal Article

Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

Yi Cao

Journal Article

Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Journal Article

Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice

ZHU Lidong, CHEN Xiaoping

Journal Article

Factor analysis for the statistical modeling of earthquake-induced landslides

Jeng-Wen LIN, Meng-Hsun HSIEH, Yu-Jen LI

Journal Article

Analysis on the distinguishing features of traditional Chinese therapeutics and related statistical issues

Jingqing Hu, Jie Qiao, Deying Kang, Baoyan Liu

Journal Article

Recent development on statistical methods for personalized medicine discovery

Yingqi Zhao, Donglin Zeng

Journal Article

Statistical considerations for genomic selection

Huimin KANG, Lei ZHOU, Jianfeng LIU

Journal Article

Statistical process control with intelligence using fuzzy ART neural networks

Min WANG, Tao ZAN, Renyuan FEI,

Journal Article

Assessment of temporal and spatial variations in water quality using multivariate statistical methods

Xue LI,Pengjing LI,Dong WANG,Yuqiu WANG

Journal Article

Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle

Zhonggao Wang,Zhiwei Hu,Jimin Wu,Feng Ji,Hongtao Wang,Yungang Lai,Xiang Gao,Yachan Ning,Chengchao Zhang,Zhitong Li,Weitao Liang,Jianjun Liu

Journal Article

Scientific significance of ancient maps of Yellow River and Grand Canal for water conservancy in China

Xiaocong LI,

Journal Article

Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Journal Article

Increasing significance of advanced physical/chemical processes in the development and application of

RULKENS Wim

Journal Article

Application of statistical design for the production of inulinase by

M. DILIPKUMAR, M. RAJASIMMAN, N. RAJAMOHAN

Journal Article